One of my favourite parts of the con, Artist Alley is filled with local (and not so local) talent. You can find stained glass, fuzzy bats and lots and lots of drawings. There's a heavy slant on comic and anime art, but you can find other things as well (I got some great gothic magnets for a friend).
I also loved the Portal inspired buttons. Cake, anyone?
And here's a video of Olivier Coipel, one of many artists sketching at the con. Here he's shading a picture of Storm.